Coenzyme Q10- Ubiquinone-CoQ10- cancer and heart health

I am a long term cancer survivor who has been through aggressive conventional therapy as well as non-conventional therapy.  The aggressive conventional therapy did little for me other than give me short, long term and late stage side effects.

http://peoplebeatingcancer.org/about-david

I have blogged frequently about many supplements that I take which have demostrated anti-cancer properties.  CoEnzyme Q10 or Ubiquinone , is one of these supplements.

"A large amount of laboratory and animal data on coenzyme Q₁₀ have accumulated since 1962. Reviewed in [2] Research into cellular energy-producing mechanisms that involve this compound was awarded the Nobel Prize in chemistry in 1978. Some of the accumulated data show that coenzyme Q₁₀ stimulates animal immune systems, leading to higher antibody levels,[13] greater numbers and/or activities of macrophages and T cells (T lymphocytes),[13,14] and increased resistance to infection.[15-17] Coenzyme Q₁₀ has also been reported to increase IgG (immunoglobulin G) antibody levels and to increase the CD4 to CD8 T-cell ratio in humans.[18-20] CD4 and CD8 are proteins found on the surface of T cells, with CD4 and CD8 identifying helper T cells and cytotoxic T cells, respectively; decreased CD4 to CD8 T-cell ratios have been reported for cancer patients.[21,22] Research subsequently delineated the antioxidant properties of coenzyme Q₁₀.[23,24] Reviewed in[25-27]"

http://www.cancer.gov/templates/doc.aspx?viewid=0e5b4097-610c-4a49-844f-d935f1d7bb07&sectionid=13&version=1&print=1

CoQ10, in addition to having anti-cancer properties,  offers me the possibility to manage my heart health. I hope to at least stop the decline of my heart damage.  My cardiologist told me last week (1/17/11) that I had permanent heart damage from the V.A.D. therapy- part of the "aggressive conventional therapy" that I refered to above.

1) My "ejection fraction" is 43%

2) Dilated aorta- sinuses are 5.7 cm. Mid ascending is 4.3 cm.

Anthracyclins have a long history of heart damage.

"Anthracyclines cause free-radical damage to cardiac myocytes, leading to mitochondrial injury and subsequent myocyte cell death.^[4] Doxorubicin–ferric iron free-radical complexes might contribute substantially to the cardiotoxicity of anthracyclines,^[5] providing the rationale for clinical use of the iron chelator dexrazoxane as a cardioprotective agent."

http://peoplebeatingcancer.org/article/therapy-insight-management-cardiovascular-disease-patients-cancer-and-cardiac-complications-

Like most non-conventional therapies, there is little evidence to prove CoQ10's cardioprotective value beyond a shadow of doubt.  I intend to continue CoQ10 supplementation and report back to you with my results.

http://www.mayoclinic.com/health/coenzyme-q10/NS_patient-coenzymeq10/DSECTION=evidence

http://www.optimal-heart-health.com/coq10.html

Does anyone have experience with CoQ10?

thanks

David Emerson